Hi Chris! I have a 15 month old who is on Cortef. 2 cc at 6:00 am, 2 cc at 2:oo pm and 3 cc's that should be given at 10:00 pm that we usually give closer to 9:00 pm. We don't seem to be having any "sleep" disturbances but we get all 3 kids up between 6 am and 7 am since we both work full-time. I do give her her last dose prior to giving her her last bottle. Hope this helps!