I'm not surprised that you haven't heard of using suppositories - our Pediatric Endo hadn't either.It was the specialist in the hospital where she had her first surgery that told us about it. However, before they could give them to us our daughter Elena had to undergo a test for absorbtion as not everybody absorbs it well.It was simple really - a blood test before and after giving the suppisitory to measure the levels of absorbtion.Luckily for us she absorbed it incredibly well. They come in two doses- 25mg and 50mg and are only for use in an emergency.We use the 25mg one. I'm not sure how it compares with the IM injection but as she absorbed it so well in the test we assume it provides roughly the same cover- otherwise the specialist wouldn't have perscribed it for her. There are a couple of drawbacks with them though, they are no good if the child has diarrhoea, for obvious reasons! and they only have a short shelf-life- approx 5 months. They are a little more expensive than the IM injection and we have had to throw out some - but we think they are worth it, especially if someone else is looking after her. The girls at her day-care centre all know that if she becomes very sick they can just pop one in and call us- much easier than asking someone to learn to inject. Hope this info helps. Heather