I wondered the same thing. Since we have been on pills, things seem to be more evened out..no big yoyos in things. I have been talking with a Mom who's nonsaltwasting daughter cannot get the testosterone down to a normal level. I believe they are are checking into another opinion as far as endos go....but I can't help but wonder if the dosing is getting messed up by the liquid cortef. BTW..by son does not seem to think the pills are bitter at all. He chews them up like a vitamin!