Make sure you are giving food/formula/breast milk w/ meds as the cortef or cortisone can be very hard on the stomach. I now give an ounce or two of formulas then the meds and then finish my sons bottle. He would throw up the medicine if I gave on an empty stomach, others have suggested the timing of the cortef also caused distress. If that doesnt help you may have a reflux problem and you should she someone sooner rather than later. Have you tried different formulas? That could be a problem also? Good Luck!