dear gareth, i believe that cortef definetly makes cah children have mood swings. i have a child, girl, with cah and i was besides myself over her crankynesss. i think that over surpression is a sign of moodyness. i found a cure for this side affect of cortef!!! i sort out a Homepathic Doctor which i personally had sucess with. the Homepathic doctor gave my daughter a remedy, which is 100% natural, and her moodyness disappeared!!! we even reduced the amount of cortef she was taking. her personally is absoulutely beautifull!!