There is no doubt in my mind that high OH-17 levels equal bad behavior. More aggression, moody, will cry over anything. Our Endo is slowly coming around to our way of thinking since some unscheduled blood tests (based on our observation of behavior) has proven this theory. She first said absolutely not, but now I think she agrees. The problem has been much more stable since we switched our 3 year old to Cortef tablets.