I don't know of any studies about depression & CAH, but maybe someone on the Late Onset CAH board or the Addison's board does (i.e. adrenal insufficiency & depression). These boards have links at the left margin (close to the end) of the "old format" CAH board. Many, many people on those board claim depression is a side effect of adrenal insufficiency. Is your friend a salt-waster or non-salt-waster?