Jill, you opened the proverbial can of worms on this one. There have been numerous debates on this subject and I doubt we'll ever reach a concensus, most likely because we're all so stubborn! :) Everyone has different routines; you need to figure out what works the best for you. I only get labs once a year and two hours after the morning dose, whenever time that dose might be taken. Roberta, on the other hand, swears by a strict dosage schedule and early morning blood draws because of the morning hormonal surge (which I'm still not convinced exists, but I'll keep an open mind). You might try to search the archives on this subject; I'm sure there are plenty of useful posts there.