It is so interesting to hear of everyone's experience with different medication levels, and I must say this is one area that still concerns and confuses me a lot. My son is almost 7 yrs. old, weighs 78 lbs., and takes only 2 5mg. cortef pills a day, or a total of 10mg/m2/day. Compared to your son, who is not quite 2, but has been on more than 2x the dose in the past, it just doesn't seem to make sense. It must have to do with being salt-wasting or non, and the starting levels in each child. Still, for a 78 lb. kid to take only 10 mg. compared to a one-year old taking 21 mg., something seems totally out of whack! Can anyone illuminate us?!!!! I am also very interested in what your doctors tell you are acceptable levels for 17OHP. My son's recent levels came back at over 400, up from 179 the previous month. I was at first concerned at the jump, and also concerned at whether or not, with the 400 number, he is being suppressed adequately. My son's doctor is the famous Dr. New in NYC, and they told us that for Nick, anything between 200-1000 was acceptable. Obviously, because Dr. New is considered the best in the world for treatment of CAH, I have to accept that her docs know what they are talking about, but I have to admit that everything I have read elsewhere points to a much lower threshold. When I quizzed Dr. New's associate about why so many other doctors seem to go by much lower numbers, she seemed genuinely puzzled. I do not feel satisfied yet about the discrepancy between doctors, and what levels indicate adequate, versus under-or-over suppression, at the same time, I don't think it is time to start panicking and think that most doctors are quacks (even though many apparently are.) I do feel that there are probably many issues to consider, including making sure levels are all given in the same units( usually ng/dl), so that one is comparing apples to apples; taking into account the time of day medicine is given (because levels of 17OHP naturally fluctuate during the course of the day, even in non-CAH people); taking into account the time of day of the blood draw; taking into account the time of the blood draw compared to when medicine was given; etc., etc., etc. Depending on all of these conditions, I believe it would be quite easy to get the wrong impression about whether or not a CAH child is being adequately controlled. I would really like to hear what other people's doctors have told them. At the same time, I know I often have to tell myself not to panic just because someone's doctor told them something different than what my own doctor has told me. What is right for one child may not necessarily be right for another. I feel that the information I get is just more pieces to the puzzle of CAH. If nothing else, differing opinions and information is a good starting point for asking the doctors just exactly what is going on.