I mentioned in another posting that I spoke with our Endo last night and she approved the change from A.M. to P.M. Lynn, I also asked her about the behavior changes. She felt that it was not related to the change in times. She feels that the Florinef can be given anytime of day as long as it is consistantly done from day to day. However, she did note that the parents on this board are likely to notice things that doctors might not. Good luck and let us know if his behavior changes back to what it was prior to the change in the florinef. I know I am interested because we are going to begin with the P.M. this evening. Judy