Lynn, I was afraid you were going to ask. Are they saying that your husband completely lacks the defective (CAH causing) gene that you have? I don't see how this could be since your husband would be unable to pass along a normal copy of that gene to your son or any of your children. They would all have CAH!! Not only that, if he completely lacks a gene necessary to make a cortisol enzyme then why doesn't he have CAH? Is it possible that it is better to lack that particular gene entirely than to have two defective copies? I certainly don't know the answer or even whether I've made a valid assumption about your husband's results. I remember speaking to one of Dr. New's Research Fellows years ago about the genetics of my own 21-Hydroxylase enzyme deficiency, the one that causes salt wasting CAH. She said that there was evidence that there is more than one gene involved. This may be the only answer for now; that there are other, unknown, genes involved that the doctor's simply have not yet discovered. This is one of the things that makes Dr. New's job so interesting and yours so difficult. Joan