Susan, I don't have any add'l information. I just remember the endo saying that they thought it shut off at approx 3am and thought 2am would be the time to get the dex. Not everyone might agree but one of the many reasons we choose not to do the study was the time to be administered. For us there really were many reasons not to partake but this was one of them. I myself more so than my husband was concerned about the time. I am not an advocate of broken sleep especially for children. All I could think of was what it would be like when he was older as well, away at college maybe.....?? who knows I just didn't like the time. Oh... it seems to me she mentioned that they were already doing the study somewhere in Europe and they had found good results with it. I don't know if that helps. Judy