Hi Concerned Mum, I looked back through the file of messages, etc that I have printed off on CAH and found a lot of posts (look in archives) on this message board from April 27 (and around there) of this year. Quite a few folks wrote in about headaches. Also if you go to http://www.healthanswers.com/Adam/top/print.asp?filename=000357.htm you will find that headache is #1 on the list (on page 2) of symptoms of an adrenal crisis. Both of the crises that I have had as an adult started out with a horrible headache. I get headaches very often and I can easily say that I would bet my life that for me it is related to low cortisol. I never get headaches unless my cortisol is low and when I do, I immediately take a small dose of Dexamethasone (I usually take .125 - .25 and my normal daily dose is .625)anyway, within 40 minutes that headache is completely gone. It's definitely related, no endo has ever told me it is (or even asked if I have headaches) but they don't have to. At 40 years old I know my body, and the headaches are CAH related - no question. I wasn't diagnosed until age 19 (but had all the signs, precocious puberty, slight physical abnormality, hirsutism, etc, but the one thing that was a daily occurance before diagnosis was a headache. I went to an ear/nose/throat doc thinking it was a tumor, or whatever, who put me on valiums (I was 14 and it WAS the 1970's) anyway, the headaches were debilitating. I'd come home from school each day and only want to go to bed because my head hurt so bad. I remember talking to my choir teacher about it and not being able to figure out what it was. It wasn't until we figured out that I was NEVER going to get a period that my GP finally got serious and sent me to Seattle to a very well known endo and I was diagnosed. I sent for those chart notes several months age (from 1978) and was surprised to see that 1 month after starting Dex I had my first period ever (the doc was excited too) and that my headaches had disappeared. I wish I did have some concrete information (studies) that had been done on low cortisol and headaches (why the headaches?) but I don't know of anything. Susan A.