Lynn it's natural after all you've been through to be upset so please don't beat on yourself. You have done everything you can and now is the time to trust yourself and trust the PEOPLE that you have seen and spoken with personally. That's an important difference. Upjohn is a giant faceless corporation but this time you are dealing with people like yourself who understand and will come to know Ryan as a little boy, not some nameless consumer of their products. At the risk of repeating what you have already been told and what you already know, for Ryan's sake as well as your own, put your mind at rest. It is going to be alright. There may be a silver lining in Ryan's symptoms, dare I say growing pains. You described similar symptoms when he was experiencing rapid growth while he was grossly under suppressed. Perhaps the growth hormone is now causing growing pains. The reduced appetite may also be a sign that he has grown into his present dosage and an increase will be due in the near future. It may a good idea to have his levels checked since his dosage will need to be increased as he grows and I think that it would help calm your fears. Peace, Joan