I think we're all just looking for some continuity among others with the same disorder. Wouldn't it be so easy if there was a formula to follow that could determine EXACTLY how much cortef YOUR child would need to keep his levels in control. We don't even have the luxury of having any two doctors that agree on what is the perfect OHP level so how could we expect to get lucky here. Each child is an individual and as such metabolizes meds at a different rate. That is something that can't be added to a formula. It is the unknown factor. For instance, it took me 24 shots in my epidural to deliver my daughter and they couldn't keep me numb for the c-section with my son. Ouch! They said they had never seen such a thing before but that each person is different and there is a first time for everything. So, I guess what I am saying is that whatever it takes to get the job done is what we need to give our kids. Like Kare said, the important thing is to keep the levels in good control. We are supposedly replacing something that our children's body can not make. As long as they are not over or under suppressed it shouldn't really make a difference how much their dose is. I am glad we ran this thread though, I found it very interesting. I'd actually like to run one sometime looking at this information again and including the OHP levels as well. Perhaps we can do it once all the switches have been successfully made. Hope all is well and have a great weekend!!!!