Thanks for the reply Carol. You brought up very good points. That is partially what I am looking for. Just anything I may be missing. Let's see to answer questions .. . Jack is a salt waster. He was diagnosed 7 days after birth. Our state has new born testing. He had some signs at birth = hyperpigmentation, kept losing weight. The newborn screen came back at 7 days after birth. They called us to the hospital for further tests. I don't have all the results but I know his 17OHP was 400 (newborn range is 7-77). His sodium and potassium were so out of wack they immediately sent us to the Children's Hosp. He was admitted and we were told to prepare for heart damage as his potassium was so high. We were lucky. There was no damage. When he was under good control he was taking Florinef and liquid Cortef. Florinef .2 mg/day one tab in am one in pm, then reduced at about 6 months old to one .1mg tab in am. He was on the Cortef, 3 times a day. I have always stuck pretty close to 6:00am, 2:00pm, 10:00pm. With his first endo (we were with her almost a year) we didn't have the same conditions with the blood draws. I learned about that from this board. That is one of the reasons we switched from her. I didn't realize I shouldn't give am meds prior to the draw. So who knows, maybe he wasn't in as good of control as I thought. Now we always have the tests at 7:00 - 7:30 am, no meds prior. As far as the oversuppression/undersuppression goes. . . When we switched endos, and therefore began not giving meds prior to early a.m. draw, his levels went up (17OHP 4278). We kind of expected this because he was due for a med increase and we had started drawing prior to a.m. med. We increased his dose but his levels went up again. We increased again and his levels plummetted (17OHP went to <5). Then we kept the same dose for 6 weeks just to see. His levels stayed low (17OHP 29). This is when I said we HAD to switch to pills. We reduced dose, switched to pills and he has continued to be oversuppressed since. The weird part is that those few draws where his blood levels showed undersuppression, his clinical exam showed oversuppression. Sorry for the long message again. Maybe something I said triggers some new idea from someone. Thank you for the good thoughts. I try not to worry too much and instead just enjoy him (but keep my eyes and ears open to). Thanks again.