After my son changed to the tablet this past summer, his counts were within the "range" (upper quadrant), yet he showed multiple signs of oversuppression. The doctor has lowered his dosage (twice since then)and the the signs are diminishing, but we won't get the next count until February. Anyway, the doctor told me that doctors disagree what is best -- the bottom of the range, the top, or the middle. This imperfect medicine apparently varies from patient to patient, even though "normal" has been defined. Lynn