How many times a day are you taking it?? You should try to space the doses evenly, for them to work properly, eg: if it says twice a day - that means every 12 hrs, if it says three times a day - every 8 hrs; if this means getting up in the middle of the night, do it. The medication will be most effective if the levels are as constant as possible in your body. If you are taking it only once a day, then taking it morning or night won't matter, as long as you take it at roughly the same time each day. I think that the company that makes the drug probably recommends taking it during the day because it can upset your stomach, and you don't want to do that just before bed if you don't have to. If you are only taking it once a day, and find that it's bothering you, you can likely try taking it in the morning instead, but you should OK it with your doctor first, of course. In the meantime - relax and enjoy your pregnancy!! You're doing the right thing for your baby! Blessings.