I also used to be musch more concerned than I am now in regards to the side effects of the cortef. I remember panicing when my son was a baby in regards to vaccinations. I read in the insert that anyone on this med should not have them. When I questioned the endo she reassured me that I must remember that the med is a REPLACEMENT and this info didn't regard him - that it was only for people taking this on top of their bodies already produncing it. However, I am concerned about the possibility of osteoporosis. Someone just posted info they learned from Dr. Pang at the Magic covention that this possibility is more real than ever. At my sons next appt. I will be questioning his doctors about that. Anybody else know anything?