Lol Valerie---your childs doctor sounds just like mine.  So blaze about the med times it is not true.  As far as I knew the meds are out and excreted anything from 6 to 8 hours and therefore any gaps between cause breakthrough of androgen.  I don't know what a doctor's idea is in advising differently---I wonder sometimes if they just don't want us beating ourselves up about being late with the meds and therefore say do this do that.  Agter all, sometimes we do forget and this cannot be helped---an occasional lapse is okay--that is what your doctor should be adivising. All I can say is, it is much easier to give Jared his 11.30 pm dose of cortisol now with the syringe.  He doesn't even have to sit up and I don't have to worry---I know he is going to swallow it.  With the tablets I would have to make him sit upright and take a glass of water and I would stand there for 5 minutes telling him to wake up.  He would be looking at me like he'd never seen me in his life before!  Obviously well and truly in the land of nod and totally out to it.  It has taken him some considerable time to wake up and then he complains about it and says he can't get back to sleep!

Before we changed from tablets to syrup, we were the same.  You try to precariously balance the meds around school and home and having a life.  This on top of cutting him back on his meds at one point because he was oversuppressed, actually did not help and he became undersuppressed.  I therefore gave in and just went with the 8 hour schedule.  He gets his meds at 7.30 am before his breakfast, his afternoon dose as soon as he walks in the door from school at 3.30pm and then I give him the last one just before we hit the sack at 11.30pm.  It works for us anyway, and I'm hoping that his levels settle back to normal and that it is just a case of getting the total daily dose tuned to his needs.  Some kids metabolise cortisol faster than 8 hourly, but you would need to stick with that regimen for quite some time and strictly before you could surmise that your child is a faster metaboliser.  If you have been out (and we were sometimes 12 hours out---even asked our endo once about this and he said word for word what yours did!) you would need to get his dosing to the strict 8 hours before they would want to look at changing it.  My son has been a two times a dayer before now and been well controlled--- don't ask me how---but I guess as they grow they can change.

JH