Dr. Pang did mention at this year's MAGIC convention that they are starting to see situations where there has been a loss of bone density. I'm sorry that I can't remember if she is doing a study or not. But I do recall that she indicated that it was showing up in "some" patients as early as 12-15. By the way, MAGIC and the MAGIC conference is WONDERFUL. Olivia and I were there for the first time this last summer. Barring unforeseen circumstances, we will be there next year.