When we decided to have another child after our son was diagnosed with CAH, we decided to go ahead with the dex therapy. We figured that 9 months was easier to handle than possibly having problems for the rest of her life. When I found out I was pregnant, I started taking the dex (about 5-6 weeks). The first dose I was put on was 12 mg./day (4 mg 3x). I believe now that that dose was way too high for me, but was following doctors recommendations. By 11 weeks I was terrified about how I would handle the rest of the pregnancy because I was having so many side-effects. I had gained 30 lbs, had facial hair, acne, irritibility, no sit (I always had to be moving). At night I woke up in extreme pain if my knees weren't elevated. I couldn't sleep on my sides because of water retention in my hips. It was terrible and all I could think of was "how am I going to do this for another 6 months?". At 11 weeks I saw a specialist and he reduced my dose to the lowest "safe" dose (the lowest dose to still see the positive results). Over about 6 weeks I went from the 12 mg/day to 1.5 mg/day (.5 mg 3x). After the reduction I was 100% better. I only gained 1 lb per week for the final 30 weeks of the pregnancy, and overall felt really good. When my daughter was born, she had no virilization at all. We still don't know if she turned out the way she did because of the extremely high dose of dex in the beginning, or if she would have been fine at the 1.5 mg dose the whole time. To me not having to make the decision about what to do about surgery made everything I went through worth it - even the stretch marks. I don't mean to scare you off with the description of what I went through, but I know that if someone had told me, it may have made it easier. The only suggestion I have is make sure your doctor puts you on the correct dose for you - and ask questions. If I hadn't asked about a lot of the problems I had, I may have had to be on the 12 mg the whole time. Good luck, and please let me know how things go if you decide to have another child. By the way - having our second was the best choice for us, and we wouldn't give her up for anything. Take care! Becki