Michele, Your question is not stupid. It is just a guess (so take for what it worth), but I would think some is possible. I base this on the fact that at each ped endo appointment the doctor carefully checks my daughter's cliortis. This is just another check to help determine if she is receiving the appropriate amount of Cortef. FYI, my daughter does not have an enlarged cliortis -- her ambiguous gentilia is that she has absolutely no vaginal opening. I will be interested in what the doctor has to say.