Nope I don't think it's your eyes. I saw this some times ago, but because Shaun posted the britannica one, I didn't bother posting this. Then when Laura asked the other day, I tried to click on the URL Shaun had sent me by e mail for the Britannica one so that I could post it here too and it didnt work. Though it did the other week..ummm So did you note Carol what it says about Growth Hormone being produced 2 hours after sleep. this is even though th cortisol levels are low and the andgrogens are nowhere in site either! Also, it states that cortisol is produced around the way a person sleeps. I surmise that the dosing of such then could affect the way the kid sleep if they are dosed dfferently to the way cortisol is naturally produced. I mean shift (night) workers can alter their whole production I suppose around just working at nights and sleeping during the days according to what this says above. I was wondering if that was why Ash felt tired in the afternoons on the prescripted dosing and especially when you consider that we were dosing 10-11pm at night when cortisol is not even produced. By all accounts he was getting the peak then instead of the 8am dose. According to tha graph, thats where the biggest dose of cortisol should fall as Laura says. I think the real trick to treating these kids is to remember that we are trying to emulate the body's rythyms and doses at the time that they would naturally happen. Not dose them at the other times to just make sure that there is enough at that time in the morning to cover them. I was going to Ask Ash's doctor on Friday and I am interested to see what he says when I show him this graph and that paper that Laura sent to me.