It looks like a different abstract. I was looking at the second paragraph in your post: *** 36 patients took part in the study, 13 male and 23 females between 6.1-18.8yrs. 14 prepubertal and 19 pubertal. 22 were on 2x dosing with biggest dose in the morning and 14 were 3x dosing. During the study the 2x dosing was 9am and 2100h and 3x at 8am,1500 and 2200h.. The patients were split into to groups. Group 1. 8 on 2x and 9 on 3x with group 2. 14 on 2x and 5 on 3x. *** Where it says the x2 daily dosing was 9am and 2100h and the x3 a day dosing was at 8am, 1500 and 2200h, it sounds as if that was the regime of dosing that the children were on 'before' they started running the 4 hourly 17 OHP testings for the 24 hour profiling? They would have done that first before they actually switched to the newer regime in the children with androgen breakthrough on the conventional dosing. Then when they switched they could purely study only those that had problems with conventional dosing on the new regime to see if it addressed their problem. (I had a thought---if your child's conventional doses of x3 per day at 8am,3pm and 10pm were not enough, and you did not want to raise the total daily dose, you could technically just switch it to this way of dosing and it would probably solve your problem for a while---and be a little too much if anything :) After that they would have switched to the dosing between 0400 went onto the new regime with the largest dose at the am as - 1600 hours and rung the 24 hour profiling for that.opposed to the pm? It's very confusing actually---and I wish I could see the whole abstract. I mean those times above are the conventional way of dosing are they not?