J Clin Endocrinol Metab 2001 Apr;86(4):1511-7 Related Articles, Books, LinkOut Growth hormone therapy alone or in combination with gonadotropin-releasing hormone analog therapy to improve the height deficit in children with congenital adrenal hyperplasia. Quintos JB, Vogiatzi MG, Harbison MD, New MI. Department of Pediatrics, Division of Pediatric Endocrinology, Weill Medical College of Cornell University-New York Presbyterian Hospital, New York City, New York 10021, USA. Short stature in the adult patient with congenital adrenal hyperplasia (CAH) is commonly seen, even among patients in excellent adrenal control during childhood and puberty. In this study we examine the effect of GH therapy on height prediction in children with both CAH and compromised height prediction. Leuprolide acetate, a GnRH analog (GnRHa), was given to patients with evidence of early puberty. GH (n = 12) or the combination of GH and GnRHa (n = 8) was administered to 20 patients with CAH while they continued therapy with glucocorticoids. Each patient in the treatment group was matched according to age, sex, bone age, puberty, and type of CAH with another CAH patient treated only with glucocorticoid replacement. The match was made at the start of GH treatment. Of the 20 patients, 12 have completed 2 yr of therapy. After 1 yr of GH or combination GH and GnRHa therapy, the mean growth rate increased from 5 +/- 1.9 to 7.8 +/- 1.6 cm/yr vs. 5.4 +/- 1.7 to 5 +/- 2 cm/yr in the group not receiving GH (P < 0.0001). During the second year of treatment, the mean growth rate was 6 +/- 1.6 vs. 4.2 +/- 2.1 cm/yr in the group not receiving GH (P < 0.001). The height SD score for chronological age in the treatment group at the end of 1 and 2 yr of treatment improved significantly more than the nontreatment group (P < 0.01). A similar improvement in the height SD score for bone age was found in the treatment group after 1 (-1.4 +/- 0.9 vs. -1.7 +/- 0.9; P < 0.0001) and 2 yr of therapy (-0.67 +/- 0.68 vs. -1.7 +/- 1.2; P < 0.0004). The mean predicted adult height improved from 159 +/- 11 (baseline) to 170 +/- 7.5 cm (after 2 yr of therapy) closely approximating target height (173 +/- 8 cm). All patients continued the hydrocortisone treatment. In patients with CAH and compromised height prediction, treatment with GH or the combination of GH and GnRHa results in an improvement of growth rate and height prediction and a reduction in height deficit for bone age. PMID: 11297576 [PubMed - indexed for MEDLINE] ------------------------------------------------------------ Summary Brief Abstract Citation ASN.1 MEDLINE XML LinkOut Related Articles Genome Links ProbeSet Links Nucleotide Links OMIM Links PopSet Links Protein Links Structure Links Sort Author Journal Pub Date AND I FOUND ANOTHER ONE HERE TO: Endocrinol Metab Clin North Am 2001 Mar;30(1):121-35 Related Articles, Books, LinkOut New ideas for medical treatment of congenital adrenal hyperplasia.Merke DP, Cutler GB Jr.Warren Grant Magnuson Clinical Center and the Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development of the National Institutes of Health, Bethesda, Maryland, USA. dmerke@nih.govDuring the past 50 years since the discovery of cortisone therapy as an effective treatment for CAH, many advances have been made in the management of 21-hydroxylase deficiency. Despite these advances, the clinical management of patients with CAH is often complicated by abnormal growth and development, iatrogenic Cushing's syndrome, inadequately treated hyperandrogenism, and infertility. New treatment approaches to classic CAH represent potential solutions to these unresolved issues. At the National Institutes of Health, a long-term randomized clinical trial is investigating a new treatment regimen: a reduced hydrocortisone dose, an antiandrogen, and an aromatase inhibitor. Peripheral blockade of androgens may also be helpful in the adult woman with CAH and PCOS. Other promising new treatment approaches include LHRH agonist-induced pubertal delay with or without growth hormone therapy, alternative glucocorticoid preparations or dose schedules, CRH antagonist treatment, and gene therapy. The applicability and success of these new approaches await the results of current research.Publication Types: · Review · Review, Tutorial PMID: 11344931 [PubMed - indexed for MEDLINE] Regards Val