Do these people ever learn anything? It just seems to me that all they seem interested in with this abstract is confusing the issues about dosing. Nothing is mentioned about reducing side effects or mood swings or so on and so forth. To my mind they are looking the gift horse right in the mouth and truing a blind eye. The whole point of Moeller and Hindmarsh and Brookes philosophies in dosing is to lessen side effects by emulating the normal circadian rythyms of cortisol. Thus cutting down the amount that you give a child and "when" you give it to effect good normal growth. Look at all the abstracts that I posted on Growth hormone. Even one there by Maria New herself posted on the Pub Med site in July this year to state that CAH children end up short stature die to excess glucocorticoid treatment! If you dosed the same child with all the different ways then on once daily dosing, your looking at a large amount of HCT for one. Twice daily would mean cutting that somewhat and dosing three times per day means using even less steroid to achive the same thing. Four times a day even less still. Following the circadian rythyms the least of all. Surely at the end of the day, we are meant to be achiveing suppression with as little amount of steroid as possible and WHEN the child REALLY needs it in order to effect good normal growth hormone production, cut side effects and cater to the childs needs daily where they need cortisol the most? I give up with these guys. It looks like Moeller posted his thoughts 15 years ago and everyone STILL odsed as above and kids STILL end up short stature and over suppressed. Then Hindmarsh and Broooke have another bash and they STILL look the other way and just carry on with the same stuff. These guys must get paid an awful lot of money to do their work and to be honest, if it were their kids, do you really think they would dose in the ways that they would have our kids dosed. Would they heck! They would be looking at the natural way of doing things to make sure that their kids did not have side effects emotionally or physically. It just appears in the above abstract that they have not really thought about the long term effects on kids. All they seem to be saying is that they do not care how it is dosed as long as it suppresses androgen. No thought to how it affects the kids in the process of doing so in those five ways of dosing---no long term studies to state how it affected each child. Although if you ask me, they have had 40 years or so to know exactly what causes the poor growth and what makes these kids have side effects such as my son has had. What of the study where Brooke and Hindmarsh found that dosing in some of the above ways caused androgen breakthrough? To be honest, I know what is the right way to replace what my sons body cannot make and WHEN it needs to be given, despite what they want to do with their little experiments, and I will never really trust any endocrinologist again fater our problems. Not unless it is one with a CAH child of his own. Someone who understands the consequences for their actions and just how it can affect these children.