It sounds like she is very over suppressed Teri. The symptoms that your talking about are all cushingoid. So she is on 2.5mg pred, one half of a 5mg tab in the morning and one at night? That seems like quite a great deal really and the whole object of treatment is to suppres the HPA axis but not so much that we get the side effects or it affects growth. This is what will happen. Maybe they started her off on these doses to solve the problem way back in January when she was diagnosed? Since they scripted her the meds after diagnosis, have they made any changes at all since with the doses? What she is on at either end of the day is equivalent to nearly 12.5mg of hydrocortisone. I realise that the pred is more potent, but I am wondering if she may be better dosed three times daily and on HCT. Especially whilst she is growing. Either that or dex once daily at the top of the morning. Either that or if they are going to leave her on the prednisone they definately need to be cutting the dosses back. In fact that dose at night is a concern as I know 12 yo kids that are only on 1.5mg pred and I understand that your grand daughter is LOCAH not CAH or salt waster, which I am assuming she has some ability to make cortisol, and that that side of things is not fully impaired as it is in Classic CAH. Who is your grandaughters doctor and are they an endo or Paed or what? It really does sound like she is being over treated and especially so with the symptoms. Regards