All I know is when I read the full 7 page abstract Valerie, it states that all patients were set up on an IV drip 12 hours before they proceed to do things to acclimatize them.  (Though that in itself must have been uncomfortable as I have had one in my end for 24 hours and ripped the damn thing out myself I was so sore with it--after my caesar---for the morphine!)  Then they dosed them at the times that they should--but I am wondering if this was with IV because in the study before that they were evaluating the bio availablity of hct in the blood on the same children. I would imagine that they did the tests all at the same visit and to cut time different doctors would have been concentrating on different things with the blood collections.  Well common sense would tell me this.  So whilst some concentrated their studies on the 17 OHP and the cortisol levels.  Other's where examining the life of hct in the blood after IV and after oral etc.  They determined that by IV and by oral that AFTER the levels have peaked, it takes the SAME lngth of time for half life to low levels in both.  However, they did not address WHEN it peaked for IV versus when it oeaked for ORAL.  Well I would have to examine that---but my point is, we really need to dose orally at least an hour to an hour and a half before the anticipated peak takes place where "normal" cortisol demands from the pituitary take place.  otherwise you miss that and 17 OHP is made in the period before the pill is absorbed properly.  I mean I am not a doctor but I studied the graph Laura sent me.  If I had dosed at 3am, I would have missed the boat.  As it is I have been dosing the 7am dose at 8am and looking on the graph which she has sent me---ithere is androgen breakthrough for sure inbetween 7am and 8am.  So I have used her calcualtions to move the dose back to 7am.  It is amazing how timing will in itself affect things.  Since if I dose at 7am, there is still some levels from the 2am dose floating around and the 7am dose just boosts that. 

Anyway, I love this topic---I could ramble all day on it.  It is very interesting and I for one would wish that other parents could take advantage of such dosing.  it truly is I beleive better than dosing conventionally I feel.  Perhaps Laura, you can do the average dosing (conventional) on a chart and cut and paste it here to make the point to others that it in no way addresses the demands made where cortisol is concerned and show them where over suppression and side effects would be occuring theroetically?  That would be cool.  We could all trouble shoot this on the board.