It sounds like an excellent idea Julia.  It may not take as long as you may think to get a 1mg pill approved by the FDA--remember it is just the same as a 5mg pill, but a smaller dose.  that part will be easy.  The time release pill though may take years.  But hink about it this way...our kids are going to still be around to benefit from it well into their adulthood.  Since adults need GH just as much as kids, and suffer the side effects of wrongly dosed steroids (their circadian rythyms don't differ that much from the one illustrated) even if it does take years---it is a step in the right direction.  I did think like that before I wote to Douglas here, but then when I really reflected on things---I knew the above was basically right. 

The abstract about circadian rythyms is basically a good start in itself and will point to the fact that side effects would normally occur where excess is in the blood.  All you need then is infomration of the side effects of too much steroid---which the manufacturers would be well up on anyway.  It is the side effects of under suppression that they may need to have some explanation on.  I would give a brief explanation of side effects from any CAH web site that relates to premature puberty and accelerated growth followed by short stature in adulthood.  As you know there are many.  Sending to some of the doctors that are involved with CAH specifically would be a good idea to get their personal endorsement.  When I wrote to Douglas they were in touch with the head pharmacists at Starship Hopsital here in NZ and he personally endorsed what I had said about the clinical need for such a pill.  Usually the pharmacist is the best one to approach as they are the ones that are getting scripts for our kids and having to just give us 5mg pills as opposed to wht is written on the script as they normally would. 

I think that you are on the right track though.  I hope that you can get things organized there.  I think it is good to start small but aim high.  You can only move a pile of bolders one at a time---but it is possible to move them all with patience and slowly.  Don't let anyone put you off if you have an idea.  It pays to think big, and some have to somnetimes for us all to move forward.  This is obviously the case because otherwise we would all be still living in caves and hunting with rocks & spears. :)