We just heard back from my daughter's endo since I wrote her a letter stating why we would like to dose more in alignment to the natural circadium rhythm and thus not affect the growth hormone. She just called us back and said to go for it!! As long as Zenya can go back to sleep without any problems and if we are willing to do it then she gives us her okay! Yeah! I already know that Zenya is able to take meds with barely waking up and going back to sleep very quickly! And for us, well, we'll do whatever it takes to give her the best treatment the allows for the lowest amount of HC to adequately suppress the androgens AND (YAHOO!) not interrupt the growth hormone that's secreted at night. I am bummed as I feel we this could have happened earlier. As many articles state the first 2 years as being of ultra importance to growth and she's 21months. Well, we're doing the best we can! Thanks to all of you who helped inform us on all of this! Julia