We are dosing at 3:00am(largest dose), 9:30am, and 4:00pm. I am now thinking of asking about 4 times a day(after seeing the graphs and how each dose can be smaller and cover adequately=less side effects from too much meds). But for now we'll do it thins way. I can email you the letter I sent and the articles to back up what I was saying, if you want ideas. Our endo is wonderful and very open to suggestions and listens well. I hope yours does too. Her only concerns were interrupting my daughter's sleep patterns (she barely wakes up and goes back to sleep with out a peep. I believe this is learned from when we gave it before WE went to bed at say 10:30pm. At first she would wake up but very quickly she learned this was routine and not to be bothered with waking up. It has actually helped her sleep as now she can sleep through much noise and banging around where before she was a light sleeper!) Good luck and let me know if you want me to send the letter I wrote to our endo! Julia