We are also doing this type of dosing and it’s working GREAT!! My daughter takes meds at 3am, 7am, 12pm, 5pm. We decided to switch with, much help from Laura K whos daughters have had great success stories, because my daughter was growing poorly and had slipped in height from 25% to off the charts without anyone being concerned except us! (Her father and I are both tall with her normally projeted height at 5’10"!) So I wrote a persuasive paper to her endo and included all the research for why we thought this would be better and the circadium rhythm charts with current and proposed schedules laid over them. Well, after doing this for only 3 months her hormone levels were all the same, in acceptable levels but her height and weight jumped from off the charts up to 7th%!!!! WE were sooooo thrilled! And she is still growing...right out of clothes she’s been wearing for, I swear, almost a year! It’s definately worth it for us to get up at 3am. Now if only the big guys would make a time released meds we wouldn’t have to get up at 3am!! That’s my dream right now. I have the letter I wrote to her endo if you’d like me to email it to you I can. Good luck. Julia