I just posted something and it seemed not to go down. Try again. I posted a web page but after more searching found two pages with reference ranges for Endocrinological Tests. So I’ll cut and paste them here for you Ali. It does alter from the follicular to the luteal phase of your menstrual cycle. Just measuring ACTH and Cortisol themselves are not a good indicator for LOCAH. That is because often these have wide ranges anyway and have a rapid feedback so they are different from one minute to the next. You may have elevated levels as a LOCAH patient because your hypothalmus is continually secreting ACTH and adrenal secrete cortisol because Hypothalmus senses there is not enough. So those levels may look good. What they look to is the androgen levels after the ACTH stim tests. They would be elevated in LOCAH or CAH.
Alphabetical Test List for RPAH Endocrinology
Click on a test’s Preferred Name for further details.
| Preferred Test Name (and assay material) | Reference Range(s) |
ACTH
Plasma | < 10 pmol/L (8 -10 am range) |
AFP
Amniotic Fluid | Pregnancy: (normal 0.5 - 2.5 MoM)
15 weeks gestation - median = 16.0 kIU/mL
16 weeks gestation - median = 13.4 kIU/mL
17 weeks gestation - median = 11.2 kIU/mL
18 weeks gestation - median = 9.5 kIU/mL. |
AFP
Maternal serum | FOR PREGNANCY.
Result reported as a Multiple of the Median (MoM): normal 0.5 - 2.5
15 wks gestation - median = 27.1 IU/mL
16 wks gestation - median = 30.9 IU/mL
17 wks gestation - median = 35.3 IU/mL
18 wks gestation - median = 40.3 IU/mL |
AFP
Serum | FOR TUMOUR MONITORING.
Males and non-pregnant females: < 6 IU/mL |
BIG BIG PROLACTIN
Serum | < 1 %. Interpretation by clinician. |
CA 125
Serum | < 35 U/mL. |
CALCIUM IONISED
Serum | 1.14 - 1.27 mmol/L |
CORTISOL
Serum | 200 - 600 nmol/L. This is an 8 -9:30 am range. The 12 midnight value should be about less than one third the am value. |
CORTISOL
Urine | (a) 300 - 900 nmol/24 h
(b) 25 - 70 nmol/mmol creatinine |
CPEPTIDE
Serum (fasting specimen) | 200 - 650 pmol/L (fasting) |
DEOXYPYRIDINOLINE FREE
Urine | Free DPD (DPD/Cr) = 3.0 - 7.4 nmol/mmol creatinine |
DEXAMETHASONE SUPPRESSION TEST
Serum | |
DEXAMETHASONE SUPPRESSION TEST
Urine | |
DHEAS
Serum | Adult males: 2.5 - 12 µmol/L
Adult females: 1.5 - 10 µmol/L |
DOWNS SYNDROME SCREEN
Serum | Ranges varies with the gestational period. The assessment of the risk is calculated based on MoM of the 3 tests. Interpretation by clinicians. MoM = multiple of Median. |
ESTRADIOL
Serum | Male: < 250 pmol/L;
Female:
Follicular phase: 75-250 pmol/L
Preovulatory: 250-1500 pmol/L
Mid-cycle: 600-1300 pmol/L
Luteal phase: 250-750 pmol/L
Postmenopausal: < 100 pmol/L
Pregnant
1st trimester: 550-15000 pmol/L
2nd trimester: 15000-25000 pmol/L
3rd trimester: 25000-70000 pmol/L |
ESTRIOL
Serum | uE3 results reported as a Multiple of Median (MoM). Normal: 0.5 - 2.5
15 weeks gestation - median = 6.9 nmol/L.
16 weeks gestation - median = 8.0 nmol/L.
17 weeks gestation - median = 9.3 nmol/L.
18 weeks gestation - median = 10.7 nmol/L. |
FREE T3
Serum | 2.5 - 5.3 pmol/L (adult) |
FREE T4
Serum | Adult: 10 - 20 pmol/L
Pregnancy: 5.0 - 14 pmol/L |
FREE TESTOSTERONE
Serum | Adult male: 170 - 510 pmol/L
Adult female: < 55 pmol/L |
FREE TESTOSTERONE INDEX (FTI)
Serum | Male: 50 - 220;
Female: 0 - 11 |
FSH
Serum | Adult male: 1.0 - 8.5 IU/L;
Female:
Follicular: 1.5 - 10.0 IU/L;
midcycle: 5.0 - 20.0 IU/L
luteal: 0.6 - 8.0 IU/L
postmenopausal: 30 - 150 IU/L
prepubertal:-
girls > 2yrs: 0 - 2.5 IU/L
boys > 2yrs: 0 - 2.0 IU/L |
GAD-ANTIBODIES
Serum | 0 - 0.9 U/mL |
GLUCAGON
Plasma (fasting specimen) | 100 - 250 pg/mL. (fasting) |
GROWTH HORMONE
Serum (fasting specimen) | < 20 mIU/L. (fasting) |
HAEMOGLOBIN A1c
Whole Blood | Adult 4.0 - 6.0% |
hCG - QUANTITATIVE
Serum | Non-pregnant normal < 5 mIU/mL (1st I.R.P.)
Normal pregnancy :
1st week: 10- 30 mIU/mL;
2nd week: 30 -100 mIU/mL;
3rd week: 100 - 1000 mIU/mL;
4th week: 1000 - 10,000 mIU/mL;
2nd to 3 rd month: 30,000 - 100,000 mIU/mL;
2nd trimester: 10,000 - 30,000 mIU/mL;
3rd trimester: 5,000 - 15,000 mIU/mL.
hCG in TRIPLE TEST:
Results reported as Multiple of Median (MoM). Normal = 0.5 - 2.5
15 weeks gestation - median = 39.7 IU/mL
16 weeks gestation - median = 32.4 IU/mL
17 weeks gestation - median = 28.3 IU/mL
18 weeks gestation - median = 25.9 IU/mL |
HYDROXY-PROGESTERONE 17-
Serum | Male adult: < 8 nmol/L
Female:
follicular phase: 0.3 - 3.6 nmol/L
luteal phase: 1.2 - 15 nmol/L
postmenopausal: 0.3 - 1.8 nmol/L
Prepubertal: < 1.8 nmol/L
Newborn (to 4th day): < 50 nmol/L |
IA2-ANTIBODIES
Serum | < 0.75 U/mL |
IGF-I
Serum | Boy & girl under 6 years: 3 - 17 nmol/L.
Boys 6 - 7 yrs: 3 - 18 nmol/L
7 - 8 yrs: 4.5 - 24 nmol/L
8 - 9 yrs: 7.5 - 30 nmol/L
9 - 11 yrs: 9 - 30 nmol/L
11 - 12 yrs: 15 - 38 nmol/L
12 - 13 yrs: 23 - 48 nmol/L
13 - 14 yrs: 30 - 93 nmol/L
14 - 15 yrs: 30 - 75 nmol/L
15 - 16 yrs: 30 - 66 nmol/L
16 - 17 yrs: 30 - 60 nmol/L
17 - 18 yrs: 23 - 53 nmol/L
Girls 6 -7 yrs: 3 - 23 nmol/L
7 - 8 yrs: 6 - 27 nmol/L
8 - 9 yrs: 9 - 30 nmol/L
9 - 10 yrs: 12 - 42 nmol/L
10 - 11 yrs: 18 - 51 nmol/L
11 - 12 yrs: 24 - 60 nmol/L
12 - 13 yrs: 30 - 102 nmol/L
13 - 14 yrs: 30 - 90 nmol/L
14 - 15 yrs: 30 - 78 nmol/L
15 - 16 yrs: 30 - 72 nmol/L
16 - 17 yrs: 30 - 60 nmol/L
17 - 18 yrs: 24 - 54 nmol/L
Adult male & females:
18 - 20 yrs: 20 - 45 nmol/L
20 - 30 yrs: 17 - 42 nmol/L
30 - 40 yrs: 14 - 42 nmol/L
40 - 50 yrs: 11 - 37 nmol/L
50 - 60 yrs: 6.6 - 33 nmol/L
60 - 99 yrs: 6.6 - 30 nmol/L |
INSULIN
Serum (fasting specimen) | 15 - 60 pmol/L (adult-fasting) |
INSULIN ANTIBODIES
Serum | 0 - 5 % |
LEPTIN
Serum (fasting specimen) | Adult male 2.0 - 5.6 ng/mL
Adlut female 3.7 - 11.1 ng/mL |
LH
Serum | Children (3 - 9 yrs): 0 - 0.15 IU/L
Adult Male: 1.0 - 10 IU/L
Adult Female:
follicular phase: 1.6 - 9.3 IU/L
mid-cycle: 14 - 72 IU/L
luteal phase: 0.5 - 13 IU/L
postmenopausal: 15 - 64 IU/L |
METALLO PROTEINASE 2, 9 - PCR (RESEARCH ONLY)
| |
METALLO PROTEINASE MEMBRANE TYPE - PCR (RESEARCH ONLY)
| |
MICROALBUMIN SPOT
Urine | < 20 mg/L (spot)
< 15 ug/min (timed) |
MICROALBUMIN TIMED
Urine | < 20 mg/L (spot)
< 15 ug/min (timed) |
N-TELOPEPTIDE
Urine | |
OSTEOCALCIN
Serum | 0.7 - 2.0 nmol/L |
PANCREATIC POLYPEPTIDE
Serum (fasting specimen) | < 55 pmol/L (fasting) |
PROGESTERONE
Serum | Male adult: < 2 nmol/L
Female:
follicular phase: < 2 nmol/L
luteal phase: 5 - 90 nmol/L
post-menopausal: < 2 nmol/L
Pregnancy:
1st trimester: 30 - 150 nmol/L.
2nd trimester: 50 - 460 nmol/L
3rd trimester: 170 - 800 nmol/L |
PROLACTIN
Serum | Adult males: 1.8 - 10.5 ng/mL;
Female: 1.8 - 13 ng/mL. |
PTH
Serum | 2.3 - 6.0 pmol/L (adult) |
SHBG
Serum | Adult males: 9 - 45 nmol/L;
Adult females: 13 -110 nmol/L |
TESTOSTERONE
Serum | Adult males: 11 - 35 nmol/L
Adult females: 0 - 3.5 nmol/L
Tanner’s stages of puberty for boys:
(average values): I 1.0 nmol/L
II 2.5 nmol/L
III 5.0 nmol/L
IV 12 nmol/L
V 20 nmol/L |
THYROGLOBULIN
Serum | Adults: < 30 µg/L |
THYROGLOBULIN ANTIBODIES
Serum | Adults: < 60 U/mL |
THYROGLOBULIN RECOVERY
Serum | 70 - 130 % |
TIMPS (TISSUE INHIBITORS OF PROTEINASES) - PCR (RESEARCH ONLY)
| |
TPO ANTIBODIES
Serum | < 35 U/mL |
TRAb
Serum | < 5 U/L |
TSH
Serum | 0.5 - 4.0 mIU/L
Neonatal range : day 1: 4.0 - 35 mIU/L ;
day 2: 3-19 mIU/L ;
day 3: 1-12 mIU/L ;
day 4: 1-10 mIU/L ;
day 5: 1-8 mIU/L (ranges from literature) |
VASOACTIVE INTESTINAL PEPTIDE
Plasma (fasting specimen) | < 30 pmol/L. fasting (adult) |
THE OTHER PAGE IS THIS ONE. I’D PRINT THEM OFF AND PUT THEM IN A BINDER AS IF YOU HAVE LOCAH, THEN YOUR GOING TO NEED A BINDER TO PUT YOUR MEDICAL RECORDS AND REFERENCES IN ANYWAY.
17- -Hydroxyprogesterone (004713)
CPT 83498
Synonyms 17-OHP
Specimen Serum or plasma
Volume 0.3 mL
Minimum Volume 0.2 mL (Note: This volume does not allow for repeat testing.)
Container Red-stopper tube, serum-separator tube, or lavender-stopper (EDTA plasma) tube
Collection If tube other than serum-separator tube is used, transfer separated serum or plasma to a plastic transport tube. Include patient’s age on the request form.
Storage Instructions Refrigerate
Reference Interval
Pediatrics: See table.1,2
Age | Male
(ng/dL) | Female
(ng/dL) |
<1 mo | 53-186 | 17-204 |
1-5 mo | 35-157 | 25-110 |
6-11 mo | 6-40 | 5-47 |
1-3 y | 2-19 | 3-51 |
4-6 y | 1-34 | 4-34 |
7-9 y | 1-45 | 4-44 |
10-12 y | 1-34 | 3-33 |
13-15 y | 23-82 | 2-72 |
Adults | 70-360 | 9-400 |
Tanner Stage |
I | 3-90 | 3-82 |
II | 5-115 | 11-98 |
III | 10-138 | 11-155 |
IV | 29-180 | 18-230 |
V | 24-175 | 20-265 |
Adults:
| female: 9-400 ng/dL, oral contraceptives: 100-170 ng/dL, postmenopausal: 10-120 ng/dL |
Use Markedly elevated in patients with congenital adrenal hyperplasia (adrenogenital syndrome) due to 21-hydroxylase deficiency; evaluate hirsutism and/or infertility; assess certain adrenal or ovarian tumors with endocrine activity
Methodology Enzyme immunoassay (EIA)
Additional Information 17-OH-progesterone is the substrate for subsequent 21- and 11-hydroxylation, to produce cortisol. The two critical enzymes, 21-hydroxylase and 11-beta-hydroxylase, participate in cortisol generation. If hydroxylation, at either position, cannot take place because of enzyme deficiency, cortisol synthesis decreases, accompanied by increased ACTH. Congenital adrenal hyperplasia and adrenogenital syndrome result from lack of normal glucocorticoids and build up of precursors (mostly virilizing). Lack of 21-hydroxylase is the most common cause of adrenogenital syndrome. Congenital adrenal hyperplasia caused by 21-hydroxylase deficiency is the most common cause of female hermaphroditism.3 It is an autosomal recessive disorder. Basal 17-hydroxyprogesterone levels can be normal in late-onset 21-hydroxylase deficiency presenting as hirsutism. Such patients are described as having dramatically increased 17-hydroxyprogesterone response to ACTH.4 Patients with 21-hydroxylase deficiency have increased 17-ketosteroids, urine pregnanetriol as well as high 17-hydroxyprogesterone. 17-Hydroxyprogesterone can also be measured on heelstick blood collected on filter paper for infant testing. Prenatal diagnosis of congenital adrenal hyperplasia is possible by HLA typing, by DNA analysis, or by hormone measurements from amniotic fluid, including 17-hydroxyprogesterone.3 Some nonspecificity is seen when amniotic fluid analysis is used.5 Congenital adrenal hyperplasia with adult onset is among the causes of hirsutism and/or infertility.
Footnotes
1. Soldin SJ, Bailey J, Beatey J, et al, "Pediatric Reference Ranges for 17 Alpha-Hydroxy Progesterone,"Clin Chem, 1995, 41:S92.
2. Tietz NW, ed, Clinical Guide to Laboratory Tests, 3rd ed, Philadelphia, PA: WB Saunders Co, 1995, 348.
3. Pang SI, Pollack MS, Marshall RN, et al, "Prenatal Treatment of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency,"N Engl J Med, 1990, 322(2):111-5.
4. Chrousos GP, Loriaux DL, Mann DL, et al, "Late-Onset 21-Hydroxylase Deficiency Mimicking Idiopathic Hirsutism or Polycystic Ovarian Disease,"Ann Intern Med, 1982, 96(2):143-8.
5. Lee A and Ellis G, "Serum 17-Alpha-Hydroxyprogesterone in Infants and Children as Measured by a Direct Radioimmunoassay Kit,"Clin Biochem, 1991, 24(6):505-11.
References
Check JH, Vaze MM, Epstein R, et al, "17-Hydroxyprogesterone Level as a Marker for Corpus Luteum Function in Aborters Versus Nonaborters,"Int J Fertil, 1990, 35(2):112-5.
DiGeorge AM, "Adrenogenital Syndrome,"Nelson Textbook of Pediatrics, 13th ed, Behrman RE, Vaughn VI, and Nelson WE, eds, Philadelphia, PA: WB Saunders Co, 1987, 1220-4.
Loriaux DL, "Hirsutism,"Cecil Textbook of Medicine, 18th ed, Vol 2, Wyngaarden JB and Smith LH, eds, Philadelphia, PA: WB Saunders Co, 1988, 1446-8.
New MI, "Clinical and Endocrinological Aspects of 21-Hydroxylase Deficiency,"Ann N Y Acad Sci, 1986, 458:1-27.
Pang SI, Pollack MS, May L, et al, "Pitfalls of Perinatal Diagnosis of 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia,"Ann N Y Acad Sci, 1986, 458:111-29.
Robboy SJ, Lombardo JM, and Welch WR, "Disorders of Abnormal Sexual Development,"Blaustein’s Pathology of the Female Genital Tract, 3rd ed, Kurman RJ, ed, New York, NY: Springer-Verlag, 1987, 15-35.
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