re: Gene therapy - ???
Sep. 20th, 2002   1:15pm

I would have to say, yes, another ten years is about right.  However, if you keep reading the health parts of the paper or (like me) read items on the health news every day at yahoo you would be amazed to find what is actually happening.  Gene therapy cured SCID or "bubble boy" syndrome.  I read on the 17th about how they used Gene therapy in mice to combat a certain type of muscular dystrophy and the mice regained 40 percent of their muscle.  Also, in Toronto (I read it on the 18th, I think) they found two proteins that are connected with enlarged hearts and actually removed one or both and the heart was normal sized.  All over the place are things picking up steam.  A research center in Europe found a way to map proteins in half the time they expected and as each protein is found to affect what disease, then they can apply it to the technology up and coming to get the fix.  My husband explained it like when you use your explorer on your computer.  You start general, then you find the file (gene) you want, then you open it and there are a bunch of other files (chromosomes?), and then you find the one you want there and open it to see all the protein files that work within that file.  I might have something backwards but you get the gist I am sure.  When DNA was finally mapped it was the beginning and, in reality, that wasn’t that long ago.  The key is once they get the proteins mapped they have to fic it and then get the information to the gene.  Do they use information riding on the back of stem cells?  Maybe.  In one case they removed bone marrow and replaced it with marrow using the correct information.  I read about a "gun"  they created somewhere in San Diego where they were giving rabbits anthrax then "shooting" (painlessly) genetic information through their skin that taught their bodies how to fight anthrax.  9 out of ten of the rabbits remained fine. 

In essence, through all that rambling (and a mind that has the overal gist but can never remember total specifics, sorry), what I believe is 10 years is a good time line.  We may not be able to do as much with stem cells here in the US but in Europe they don’t have the same rules.  Between the mapping of the proteins, the testing (on mice etc.), perfecting the way to get the information into the gene, and then giving it to a human, it looks like its right around the corner.  At least now they know what they are looking for and what to do to get there!

 

Ruth
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