Anne Marie,

It completely perplexes me that you would disagree about such a basic concept.  If you do not believe that this circadian pattern persists, and at these basic times, why in the world are you getting up at 3 AM to dose your child???? I am assuming it is because you believe such a pattern exists! 

If you are arguing, instead, that circadian patterns change from day-to-day and from person to person, depending on schedule---then, everyone should be dosing at different times---since everyone’ s schedule is a bit different---and we would be back to square one.  Again, if you have gone to the trouble of rearranging dosing times based on circadian rhythm, I am assuming it is because you agree that such a thing persists!!