Anne-MarieOr are you saying that a kids on conventional dosing make 17 OHP from 3-6am (as it says in the Moeller abstract (as I thought you understood), but when they get up at 6am, they don’t make any extra from there enough to worry about in that hour to 7am? Even when the study I posted for you states that right from rising--within the FIRST 30 minutes, they make 50-60% percent of their peak where cortisol is concerned? (That is a LOT of cortisol that these kids cannot make here! So are you also of the belief that this big surge or effrot for th adrenals to make 50-60% cortisol, is not really convertd to 17 OHP or androgens anymore than it is from 3-7 in Moeller’s abstract or what? Sounds to me like you don’t really believe that it would make that much difference at all.) LOl!