Hi Susan,

Personally I don’t think you would need the same dose as you took at night if your taking it in the morning.  I’ll try to explain the best that I can.  Taken at night, it needs to be high enough to cover you at 3am and @ 7am and then last you ALL day.  ;)  Some 24 hours.  Sooo if your taking the dose now @ say 7am and to my mind, less is needed because your creating high cortisol levels in the morning, low in the evening and this is more than meeting your body’s demand obviously in taking it that way.  Of course you don’t need much after 5pm anyway until 3am.  To my mind if your taking a tablet at 7am and it is still high enough to cause such low labs at 8am the following morning (bloods drwn off before your dose I presume?) then it really still needs reducing back some to my mind.  (I thought that you were on pred but maybe getting mixed up here---nevermind).  

Even though it does not mimick cortisol perfectly (no oral corticosteroid can do that) ---it is higher in the morning after taking and lower in the evening---which is probably better than taking it @ say 10pm and having it high there where you don’t really need the high cortisol levels.  Sort of 5 hours in your system that it isn’t really needed, but peaking nevertheless and then plummeting during the day I would imagine when you need it to be covering you.  I’d drop the dose some 20% and see what happens actually if it were myself.  Especially if your getting labs like that back and they are causing any side-effects also.

You would definately need much less when taking the dex in the morning than you would need at night in my opinion.