I know that there is debate about this issue but I do not wake my kids for medication and I never have. I give them their meds right before bed, whenever that is, between 7:30 and 8:30 and upon waking the next morning at 7:00- 8:00, this has worked for my boys, both on a low dose of cortef, with reasonable growth etc...you may want to ask your endo.MarthaGood luck with the sleeping!