We were giving the injection in the outer thigh for a while and then Julia decided to get it in her butt. The first couple of times were OK, but then I think she got the sciatic (sp?) nerve. We are back to the outer thigh again. Her legs are pretty meaty and muscular, but she sometimes says it feel like it hits the bone (I doubt it). I can’t believe she has been getting them for almost 4 years!!!Beth D.Good luck to you!!!!!