There seem to be so many drugs there that relatively little is known about where long term side-effects on kids are concerned.  I guess kids are meant to have a small trace of test and androgen and basically and they doget that on conventional treatment when cortisol levels fall low enough in the few hours after a dose.  Muscle and bone are reliant on androgens for growth.  However with something like Flutamide blocking androgens--and the Doctor’s seldom really knowing half the time what "normal"  ranges should be when taking hormone levels in these kids (I mean look at what happened when they tries to follow "normal" ranges in normal kids where 17 OHP is concerned = over treatment with drugs in a CAH child), I don’t think you’d even have that trace of androgen in the kids the same over a 24 hour period.  Test and androgen’s are important for growth as above.  Knock them on the head and you obviously slow or stunt it to my mind.  The other concern for me is the cut back in cortisol.  Should it be lower than the norm as established for these kid’s, I wonder if it is really that good for kids when they are quite stressed and on such lowered levels?  Just my two cents worth.. 

I’d say if it isn’t working, get the child off them.  Gut instinct.