I posted that and then realised that it needed to be explained in further depth maybe.  I’m no Doctor but have a basic knowledge of insulin resistance and fat metabolism and what role androgens play in that also.  So I posted explaining so it would help other’s to understand.

Insulin resistance is a reduced sensitivity in the tissues of the body to the action of insuln, which is, importantly, to bring glucose into those tissues to be used as a source of energy.  When insulin resistance, or reduced insulin sensitivity exists, the body attempts to overcome this resistance by secreting more insulin from the pancreas. This compensatory state of hyperinsulinemia (high insulin levels in the blood) is felt to be a marker for the syndrome. The development of Type II, or non-insulin dependent, diabetes occurs when the pancreas fails to sustain this increase insulin secretion.

When cortisol levels fall to low levels in the blood serum as we know the hypothalmus picks this up and releases ACTH.  Now cortisol levels can decrease with sudden injury or illness or even going hard out in sport.  The minute the levels drop, the ACTH is released and this causes an insulin spike.  We also know that people on cortisol replacement or people not making enough cortisol make excessive ACTH over prolonged periods of time, and this causes insulin levels to be higher also.  Those are periods where you may uffer insulin resistance syndrome as above. 

Now insulin inhibits the breakdown of fat in adipose tissue.  It also has profound effects on both carbohydrate and lipid metabolism, and significant influences on protein and mineral metabolism.  For example normally elevated concentrations of glucose in blood stimulate release of insulin, and insulin acts on cells thoughout the body to stimulate uptake, utilization and storage of glucose. It’s stored as fat. 

At the opposite end of the spectrum, the ONE hormone that could possibly help to break down those fat cells and help to regulate things are androgens.  It has been found that people with higher androgen levels have less fatty deposits on their body and stronger bones--as well as good growth.  So as you can imagine now, because you have blocked that hormone and elevated the ONE hormone that is responsible fat storage, you have in essence created a nightmare scenario in my opinion.  So it seems lowering cortisol and blocking or lowering androgens is obviously not as effective as it sounds.  No more easier to control than just controlling a child on the only hormone they are and have been missing---cortisol.

Since they know a little bit more about the control with cortisol than the former, it is one of the reasons I stated the child should be pulled off the drugs asap before the situation deteriorates to Type II diabetes or anything worse for that matter.