Look at the title of that study:

Flutamide, Testolactone, and Reduced Hydrocortisone Dose Maintain Normal Growth Velocity and Bone Maturation Despite Elevated Androgen Levels in Children with Congenital Adrenal Hyperplasia

 

It infers that the child will have high androgen levels.  However, if both the dose of cortisol they are on and the dose of antiandrogen dose they are on blocks more than ncessary, that isn’t going to occur is it.  Further to that, the testalactone stop conversion of androgen to estrogen, yet this boy has been storing body fat and has insulin resistance, which would suggest the blockage if that isn’t working either.  Excess estrogens also lead to storing of more body fat and high blood glucose levels. 

 

I wouldn’t mind if perhaps someone here would explain how more androgen is made when an androgen blocking drug is being used?  That and why the anti estrogen isn’t kicking in in this boys case--because it is obvious his estrogen levels are higher than they should be to allow for fat sotrage.  We’ve had the non-compliance bit here, but a lot of you don’t seem to realise that parents comply and there are other reasons for things failing such as unknown side effects of drugs and their combinations and also the fact that they arn’t able to control them all in conjunction to eachother as well as they first thought.   The treatment has obviously rendered him basically with the same symptoms he might have if he were just over treated with cortisol and florinef.  They are unlikely to publish any ngative side-effects of these drugs at this stage but I am certainly not fool enough to dream there arn’t any when these drugs are quite potent and can be detrimental when not controlled properly as illustrated in this boy. Besides if it made complete utter sense and any parent was going to think in depth about it and acknowledge it was feasible I am quite sure Carol would have her son Nick on it quicker than you could say, "Where do I sign for it." LOL!  If this boy is pulled out that means there is an extra place on the program LOL... get in there Carol.  ;) :) 

I’m sure they would have you.... *snickers* 

 

Perhaps we can have a more in depth scientific explanation as to how androgen can be HIGHER in the presence of an anti androgen.  This study just says they have had some results.  So some kids managed to gorw on a specific combination of doses of each drug instead of more spioradically due to Doctors not controlling CAH properly on the basic drugs these kids need.  I doubt it is any easier to control, and as I’ve explained there seems to be more risk with conditions like insulin sensitivity and extra weight gain being known about also doesn’t it?  I mentioned that the insulin resistance and excess weight gain in that boy are typical of what I said would happen with low androgens (blocked by an anti androgen) in the presence of too high a dose of cortisol.  These things would happen would they not?  More risk to my mind.  I mean if his androgen levels WERE higher and the point of blocking androgen is to raise it (sounds cuckoo but let’s go with it for a minute guys) he would not be storing fat, he be burning it profusely and also he would be growing like a mushroom.  He has not by the sounds of it grown like a mushroom and also he has ended up with insulin resistance to boot with some excess pudginess.  Go fiigure! LOL!