re: re: High 17 OHP’s 10,000!!!!!! Help
Jun. 15th, 2003   12:59pm

Sorry to hear of your problems Brenda.  My son is 15 and the  reference range for 17OHP hasn’t changed with age:-

08.00hrs - 30-70 nmol/l (approx. 900-2100 ng/dl),        12.00hrs - less than 12 (360)

16.00hrs - less than 8 (240),                                            22.00 hrs- less than 8 (240).

Obviously since going into puberty his testosterone level has increased but this should be produced by the testes and not the adrenals, so the 17OHP levels should not rise too, although  LH and FSH levels will.  Control in puberty can be difficult and I believe patients should be monitored more closely during this period, due to the rapid growth and body changes. Also metabolism can change during this time and the half life of hydrocortisone tends to decrease, so more frequent doses of hydrocortisone are sometimes necessary.   I am sure your son can easily be brought back under control, he just needs an adjustment in medication.  A 24 hour profile (preferably done as a hospital admittance) would show exactly when he needs to take his tablets and the specialist can then work out the dose required.  If his bones have fused, there is nothing more that can be done about growth - this is very unfortunate, especially if the bone-age has advance due to inadequate suppression.  

Toni
Rare Disease Search Engine, Homeschool Sites, Online Homeschool, Online Income, Ethical Adsense, Creative writing, Family Web Hosting, Christian Radio, Tulsa Parks