We use a 8am/4pm/12 midnight schedule.  My daughter goes to bed at 8pm and wakes up at 8am the next morning.  I give her meds to her with her breakfast at 8am so she can take them with some food.  As for her 12 midnight dose, she just takes it in her sleep.  I give her a big snack before she goes to bed and I figure she still has a bit of food in her stomach for her late night dose.  We have been doing this schedule for 2 or more years and she has perfect growth (the 95th percentile for height ) and perfect weight (75 percentile) and has been following the same curve since birth (she is 4 years old now).  I hope this helps.