We dissolve our daughters meds the same way you do. . .except we just go ahead and put the pills in a syringe and suck up some water to dissolve them. Our endo said that it didn’t hurt anything and that the medicine wouldn’t lose its effectiveness by doing so. We’ve always put ours int he fridge too. . .I think that we heard somewhere that one or the other is temperature sensitive. . .but we don’t keep the pills in the fridge so who knows. . .if anyone else has a better answer let me know! If not I’l lcheck with my hubby when he gets home.Elizabeth