We use the pill form of Cortef as our doctor doesn’t prescribe the liquid form. As for the dosing, our endo has always said to get in the 3 doses in the day when they are awake and not to wake them to give it. With the Zantac and the Cortef, I don’t know any other way to do it. We are having labs done in a couple of weeks so I guess we will see if the change has affected her in any way.Cassy