SallyHi Becky, I agree with Cassy, antidepressants would be far less harmful than large doses of pred and you may only need them for a few months, just to get you feeling better. I believe you are under the same consultant as me at the Middlesex Hospital in London. Have you explained to him exactly how you feel? As a multidisciplinary clinic, there is an excellent psychologist attached to his team, who you could arrange to see on the same day as the endocrinologist - if you ask. She understands CAH well and is a lovely lady - it may just be worth you having a chat with her! We all get down sometimes, and why not take advantage of the help on offer? Good luck and I wish you well!