lisa,  I will let you know how it goes.  My endo did give his blessing.  I think most endos don’t recommend 4x day dosing and especially 3 am dosing because they don’t think compliance will be good.  If you are willing to give the 3am dose then from what I have learned it is clearly a better way to go.  As far as that dosing schedule in the moeller study, it is impossible given the 5mg tabs that are available.  So what we did was come up with our best guess for an appropriate schedule given feasability of splitting the pills and my daughters history.  We also would prefer a 230-3pm dose rather than the 12pm dose so she doesn’t have to get it at school next year.  I think our schedule makes sense and I hope it works.  The only problem I forsee is the hunger associated with the doses, about one hour after.  the 3pm and 8-9pm doses although small may promote snacking.  I look forward to posting good results in the future.  If anyone has been through this process already please post your results and the details of dosing and changes you had to make.  thanks