WE, too give the biggest in the AM.  (3am, 7am, noon and 5:30).  When my daughter had the biggest dose at night she was not growing at all.  (This is not to say that all will have this problem.  It is something to be aware of if your child is having similar problems.  Some do fine on the mor e traditional dosing of largest at night.  My daughter is more susceptible to side effects and one way to reduce these is to change to the circadium rhythm dosing.)  Julia